binder-gauntlet
Skill644 starsChanged 18 days agoNo licenceView on GitHub
Validation and developability gauntlet for de novo designed protein binders and miniproteins against any protein target. Use this skill when designed binders are scored only by structure-predictor confidence (ipSAE, ipTM, pAE) and you must validate binding with independent re-prediction, pose agreement (DockQ) and controls, profile developability and sequence liabilities, check specificity and cross-reactivity, and write a validation dossier before you rank, filter or finalise binder designs, and at every selection round of a design campaign to steer it. Use when a user says "validate these binder designs", "run the gauntlet on these", "check developability" or "sequence liabilities", asks which designs should go to the lab, or asks for controls, a specificity panel or a validation dossier for designed binders.
In this repository3 other files it gives its agents.
The file
We split this skill into the rules it gives an agent
1 rule. About 0 are common, 1 is distinctive, and 0 are very specific to this project.
≈0
Common · estimate
Many files like this have a rule of this kind.
≈1
Distinctive · estimate
This author's own choices. Worth a look.
0
Very specific
Tied to their project's names, files or tools. Probably skip.
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≈ “Common” is an estimate: at least 1 in 5 of the 350,495 skill files we read have a rule of the same kind, not the same words. “Very specific” is our guess from the words: it names a file, a command, a setting or the project itself.
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